A rat model of spontaneous myopathy and malignant hyperthermia.
Am J Pathol
; 152(4): 1099-103, 1998 Apr.
Article
em En
| MEDLINE
| ID: mdl-9546371
ABSTRACT
Malignant hyperthermia is a main cause of death during general anesthesia, particularly in children. However, research has been hampered by the lack of a convenient animal model, the only one available being a special strain of pig. In this study, we describe spontaneous myopathy and a fatal syndrome of generalized muscle rigidity triggered by halothane in an outbred strain of rat. Histological examination of skeletal muscle reveals severe abnormalities indicating chronic underlying myopathy. The association of histological abnormalities with an acute, fatal syndrome clinically resembling malignant hyperthermia provides a strong basis for a new and extremely useful animal model to study this fatal disorder.
Texto completo:
1
Base de dados:
MEDLINE
Assunto principal:
Músculo Esquelético
/
Modelos Animais de Doenças
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Hipertermia Maligna
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Doenças Musculares
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article