Effects of acute administration of delta9-tetrahydrocannabinol on pulmonary hemodynamics of anesthetized dogs.
Eur J Pharmacol
; 38(1): 183-7, 1976 Jul.
Article
em En
| MEDLINE
| ID: mdl-954827
I.v. administration of delta9-THC (2.5 mg/kg) To anesthetized dogs resulted in a decrease in heart rate, pulmonary blood flow (PBF), and a significant increase in pulmonary artery pressure (PAP) and total pulmonary vascular resistance (PVR). The increase in PVR to delta9-THC was significantly reduced by cardiac pacing, and was virtually abolished either by bilateral vagotomy or by pretreatment with hexamethonium. The data indicated the delta9-THC induced elevation of PVR was mediated via reflexogenic mechanisms involving afferent vagi and efferent autonomic pathways.
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Base de dados:
MEDLINE
Assunto principal:
Dronabinol
/
Cannabis
/
Hemodinâmica
/
Pulmão
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article