Preclinical oral toxicology in rats of D-002, a natural drug with antiulcer effects.
Drug Chem Toxicol
; 21(2): 151-62, 1998 May.
Article
em En
| MEDLINE
| ID: mdl-9598297
ABSTRACT
D-002 is a mixture of higher aliphatic primary alcohol isolated from bees wax (Apis mellifera) with effective antiulcer effects demonstrated in different experimental models. Oral toxicity of D-002 (5-5000 mg/kg) was evaluated in sub-acute (14 days), subchronic (90 days) and chronic (1 year) studies in Sprague-Dawley rats from both sexes. There was no treatment-related toxicity. Thus, effects on body weight, food consumption, clinical observations, blood parameters, organ weight ratios and histopathological findings were similar in control and treated groups. These short and long-term studies support a wide safety margin for this product.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Álcoois Graxos
/
Antiulcerosos
Tipo de estudo:
Prognostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article