Your browser doesn't support javascript.
loading
No association of the tryptophan hydroxylase gene with bipolar affective disorder, unipolar affective disorder, or suicidal behaviour in major affective disorder.
Furlong, R A; Ho, L; Rubinsztein, J S; Walsh, C; Paykel, E S; Rubinsztein, D C.
Afiliação
  • Furlong RA; Department of Medical Genetics, University of Cambridge, Addenbrooke's Hospital, United Kingdom.
Am J Med Genet ; 81(3): 245-7, 1998 May 08.
Article em En | MEDLINE | ID: mdl-9603613
Tryptophan hydroxylase (TPH) is the rate-limiting enzyme in the synthesis of 5-hydroxytryptamine (5-HT). An association study in bipolar affective disorder I or unipolar major affective disorder was performed by using a Bfa I restriction site polymorphism within intron 7 of the tryptophan hydroxylase gene. A total of 118 bipolar, 125 unipolar, and 437 control subjects were used in the study (1:3.7 bipolar:control, 1:3.5 unipolar:control). There were no significant differences in TPH allele or genotype frequencies between the affective disorder and control groups. In addition, bipolar and/or unipolar subjects with or without a history of suicide attempts were compared for the TPH polymorphism. No significant differences were found between suicidal and non-suicidal groups in major affective disorder, in contrast to a previous study suggesting an association of this polymorphism with a history of suicide attempts among alcoholic violent offenders.
Assuntos
Buscar no Google
Base de dados: MEDLINE Assunto principal: Tentativa de Suicídio / Triptofano Hidroxilase / Transtorno Bipolar / Polimorfismo de Fragmento de Restrição / Transtornos do Humor Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 1998 Tipo de documento: Article
Buscar no Google
Base de dados: MEDLINE Assunto principal: Tentativa de Suicídio / Triptofano Hidroxilase / Transtorno Bipolar / Polimorfismo de Fragmento de Restrição / Transtornos do Humor Tipo de estudo: Risk_factors_studies Limite: Female / Humans / Male Idioma: En Ano de publicação: 1998 Tipo de documento: Article