Getting the glycosylation right: implications for the biotechnology industry.
Nat Biotechnol
; 14(8): 975-81, 1996 Aug.
Article
em En
| MEDLINE
| ID: mdl-9631034
ABSTRACT
Glycosylation is the most extensive of all the posttranslational modifications, and has important functions in the secretion, antigenicity and clearance of glycoproteins. In recent years major advances have been made in the cloning of glycosyltransferase enzymes, in understanding the varied biological functions of carbohydrates, and in the accurate analysis of glycoprotein heterogeneity. In this review we discuss the impact of these advances on the choice of a recombinant host cell line, in optimizing cell culture processes, and in choosing the appropriate level of glycosylation analysis for each stage of product development.
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Base de dados:
MEDLINE
Assunto principal:
Biotecnologia
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1996
Tipo de documento:
Article