Structural characterization of a new acylpolyaminetoxin from the venom of Brazilian garden spider Nephilengys cruentata.
Toxicon
; 36(3): 485-93, 1998 Mar.
Article
em En
| MEDLINE
| ID: mdl-9637368
ABSTRACT
The use of mass spectrometry, in which high-energy CID and charge remote fragmentation both of protonated and sodium-attached molecular ions was applied, afforded the structural elucidation of a new acylpolyaminetoxin with Mw=801 Da from the venom of the Brazilian garden spider Nephilengys cruentata. In spite of having the same Mw of the NPTX-2, previously described in the venom of the Joro spider Nephila clavata, neither toxins are isomers. In order to differentiate them by using the most usual nomenclature, the new toxin was named NPTX-801C and the NPTX-2 was renamed to NPTX-801E. Both toxins have as common structure the 4-hydroxyindole-3-acetyl-asparaginyl-cadaveryl moiety in their molecules and their structure may be represented in a simplified way NPTX-801E is HO-indole-Asn-Cad-Pta-Orn-Arg and NPTX-801C is HO-indole-Asn-Cad-Gly-Put-Pta-Pta.
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Base de dados:
MEDLINE
Assunto principal:
Poliaminas
/
Venenos de Aranha
Limite:
Animals
País como assunto:
America do sul
/
Brasil
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article