Design and synthesis of m1-selective muscarinic agonists: (R)-(-)-(Z)-1-Azabicyclo[2.2.1]heptan-3-one, O-(3-(3'-methoxyphenyl)-2-propynyl)oxime maleate (CI-1017), a functionally m1-selective muscarinic agonist.
J Med Chem
; 41(14): 2524-36, 1998 Jul 02.
Article
em En
| MEDLINE
| ID: mdl-9651157
ABSTRACT
The synthesis and SAR of a series of (Z)-(+/-)-1-azabicyclo[2.2. 1]heptan-3-one, O-(3-aryl-2-propynyl)oximes are described. The biochemistry and pharmacology of 24Z (PD 142505) and its enantiomers are highlighted. 24Z is functionally an m1-selective muscarinic agonist. Efficacy and m1 selectivity reside in the R enantiomer, (R)-24Z (CI-1017).
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Oximas
/
Desenho de Fármacos
/
Receptores Muscarínicos
/
Agonistas Muscarínicos
/
Compostos Bicíclicos Heterocíclicos com Pontes
Limite:
Animals
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article