Limited CD4+ T-cell renewal in early HIV-1 infection: effect of highly active antiretroviral therapy.
Nat Med
; 4(7): 794-801, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9662370
ABSTRACT
We show that the fraction of proliferating CD4+ lymphocytes is similar in HIV-infected subjects in the early stage of disease and in HIV-negative subjects, whereas the fraction of proliferating CD8+ lymphocytes is increased 6.8-fold in HIV-infected subjects. After initiation of antiviral therapy, there is a late increase in proliferating CD4+ T cells associated with the restoration of CD4+ T-cell counts. These results provide strong support for the idea of limited CD4+ T-cell renewal in the early stage of HIV infection and indicate that after effective suppression of virus replication, the mechanisms of CD4+ T-cell production are still functional in early HIV infection.
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Base de dados:
MEDLINE
Assunto principal:
Sulfonamidas
/
Didesoxinucleosídeos
/
Linfócitos T CD4-Positivos
/
Infecções por HIV
/
Inibidores da Protease de HIV
/
Inibidores da Transcriptase Reversa
/
Fármacos Anti-HIV
Limite:
Adult
/
Aged
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article