Central nervous system toxoplasmosis with an increased proportion of circulating gamma delta T cells in a patient with hyper-IgM syndrome.
J Clin Immunol
; 18(4): 283-90, 1998 Jul.
Article
em En
| MEDLINE
| ID: mdl-9710745
ABSTRACT
Hyper-IgM syndrome represents a diverse group of immunodeficiencies characterized by normal or high serum IgM concentrations with decreased or absent IgG, IgA, and IgE. The X-linked form of hyper-IgM syndrome is caused by mutations in the CD40 ligand gene, preventing its expression on activated T cells. The CD40 ligand--CD40 interaction is critical for effective isotype switching and for initiating antigen-specific Tf cell responses. In addition to recurrent pyogenic infections, patients with the CD40L defect also have opportunistic infections. An increased proportion of circulating gamma-delta T cells, shown to be important early during primary infections, has been demonstrated in numerous infectious diseases including toxoplasmosis. Here, we report a patient with hyper-IgM syndrome and CNS toxoplasmosis, who showed a marked increase in gamma-delta T cells in his peripheral blood and who has responded well to treatment of his toxoplasmosis and to high-dose immunoglobulin replacement therapy.
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Base de dados:
MEDLINE
Assunto principal:
Toxoplasma
/
Imunoglobulina M
/
Linfócitos T
/
Infecções do Sistema Nervoso Central
/
Toxoplasmose
/
Hipergamaglobulinemia
Limite:
Animals
/
Child
/
Humans
/
Male
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article