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Does the vitamin D receptor genotype predict bone mineral loss in haemodialysed patients?
Karkoszka, H; Chudek, J; Strzelczyk, P; Wiecek, A; Schmidt-Gayk, H; Ritz, E; Kokot, F.
Afiliação
  • Karkoszka H; Department of Nephrology, Endocrinology and Metabolic Diseases Silesian University School of Medicine, Katowice, Poland.
Nephrol Dial Transplant ; 13(8): 2077-80, 1998 Aug.
Article em En | MEDLINE | ID: mdl-9719169
ABSTRACT

BACKGROUND:

It has been suggested that the vitamin D receptor (VDR) gene BsmI-polymorphism is a genetic determinant of bone metabolism.

DESIGN:

To test this hypothesis, the relationship between VDR genotypes, bone mineral density (baseline and after 18 months) and parameters of calcium metabolism and bone turnover were investigated prospectively in 88 haemodialysed patients not receiving active vitamin D metabolites.

METHODS:

Whole body, lumbar spine and femoral neck bone mineral density (BMD) were assessed by dual energy X-ray absorptiometry (DEXA). In addition calcium, phosphorus, 25(OH)D3, 1,25(OH)2D3, osteocalcin serum concentrations, alkaline phosphatase activity and intact 1,84 PTH levels were measured.

RESULTS:

VDR genotype BB, Bb and bb were found in 27, 49 and 24% of patients. Initial BMD (g/cm2) of whole body, lumbar spine and femoral neck did not differ between genotypes (whole body BB 1.055 +/- 0.120, Bb 1.082 +/- 0.102, bb 1.128 +/- 0.120; lumbar spine BB 1.075 +/- 0.199, Bb 1.079 +/- 0.185, bb 1.099 +/- 0.170; femoral neck BB 0.808 +/- 0.160, Bb 0.862 +/- 0.127, bb 0.842 +/- 0.125; mean +/- SD), but the decrease of whole body and femoral neck BMD during 18 months was significantly (P < 0.02) different between the genotype groups (whole body BB -0.048 +/- 0.028, Bb -0.031 +/- 0.029, bb -0.024 +/- 0.023; femoral neck BB -0.044 +/- 0.069, Bb -0.032 +/- 0.081, bb -0.012 +/- 0.029 g/cm2).

CONCLUSION:

This preliminary study suggests faster mineral loss in BB genotype of VDR in haemodialysed patients.
Assuntos
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Base de dados: MEDLINE Assunto principal: Densidade Óssea / Diálise Renal / Receptores de Calcitriol Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1998 Tipo de documento: Article
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Base de dados: MEDLINE Assunto principal: Densidade Óssea / Diálise Renal / Receptores de Calcitriol Tipo de estudo: Prognostic_studies / Risk_factors_studies Limite: Adolescent / Adult / Aged / Female / Humans / Male / Middle aged Idioma: En Ano de publicação: 1998 Tipo de documento: Article