Frequent somatic mutations in serine/threonine kinase 11/Peutz-Jeghers syndrome gene in left-sided colon cancer.
Cancer Res
; 58(17): 3787-90, 1998 Sep 01.
Article
em En
| MEDLINE
| ID: mdl-9731485
ABSTRACT
We analyzed somatic mutation and loss of heterozygosity (LOH) in the serine/threonine kinase 11 (STK11)/Peutz-Jeghers syndrome gene in 49 colorectal tumors in three different stages of a dysplasia-carcinoma sequence. We detected LOH in 10 of 19 (52.6%) informative colorectal cancers at loci D19S886 and/or D19S883, but no LOH was observed in 25 informative adenomas. We detected a total of 9 somatic mutations [7 of 13 (53.8%) left-sided colon cancers and 2 of 7 (28.6%) left-sided adenomas with high-grade dysplasia], but no mutations were detected in right-sided colon tumors. Of the nine mutations, one was a frameshift mutation (the same mutation detected in Peutz-Jeghers syndrome family previously), and the other eight were missense mutations. This results indicate that STK11 is a tumor suppressor gene and that genetic changes of STK11 play an important role in left-sided colon cancer carcinogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Síndrome de Peutz-Jeghers
/
Proteínas Serina-Treonina Quinases
/
Neoplasias do Colo
/
Mutação
Limite:
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article