Identification of germ-line E-cadherin mutations in gastric cancer families of European origin.
Cancer Res
; 58(18): 4086-9, 1998 Sep 15.
Article
em En
| MEDLINE
| ID: mdl-9751616
ABSTRACT
E-cadherin germ-line mutations have recently been described as a molecular basis for early-onset familial gastric cancer in Maori kindred. We screened 18 gastric cancer families of European origin for germ-line mutations to determine the proportion in which E-cadherin mutations occur and the clinical characteristics of the affected families. Truncating mutations were identified in three kindred with familial diffuse gastric cancer. In these families, the age of onset of gastric cancer was variable, the penetrance was incomplete, and one kindred contained individuals with cancers at other sites. Here, we show that a proportion of diffuse gastric cancer families of European origin have germ-line E-cadherin mutations; however, these mutations are absent in intestinal gastric cancer families.
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Base de dados:
MEDLINE
Assunto principal:
Neoplasias Gástricas
/
Caderinas
/
Mutação em Linhagem Germinativa
Tipo de estudo:
Diagnostic_studies
/
Prognostic_studies
Limite:
Adult
/
Aged
/
Aged80
/
Female
/
Humans
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Male
/
Middle aged
País como assunto:
Europa
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article