Follicle stimulating activity of human chorionic gonadotropin: effect of dissociation and recombination of subunits.
Endocrinology
; 99(4): 1126-8, 1976 Oct.
Article
em En
| MEDLINE
| ID: mdl-976192
ABSTRACT
The follicle stimulating activity (FSA) and interstitial cell stimulating activity (ICSA) of highly purified human chorionic gonadotropin (hCG), its alpha and beta subunits, and hCG generated by subunit recombination were determined by ovarian weight and ventral prostate weight bioassays. Whereas highly purified hCG exhibited both FA and ICSA, its separated subunits were essentially devoid of both activities. ICSA and FSA, indistinguishable from that of the highly purified hCG, were restored by recombination of the hCG subunits. These observations are consistent with the hypothesis that the FSA and ICSA found in highly purified hCG preparations are properties of the hCG molecule.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Gonadotropina Coriônica
/
Folículo Ovariano
Limite:
Animals
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article