[Late manifestation of common variable immunodeficiency by Biermer's disease]. / Hypogammaglobulinémie commune variable révélée tardivement par une maladie de Biermer.
Presse Med
; 27(8): 351-3, 1998 Feb 28.
Article
em Fr
| MEDLINE
| ID: mdl-9767998
ABSTRACT
BACKGROUND:
Common variable immunodeficiency (CVI) is a heterogeneous disorder characterized by decreased production of antibodies. Clinical presentation of CVI is generally that of recurrent pyogenic infections. Autoimmune diseases can also occur. The age of onset of symptoms shows two peaks at 1-5 and 16-20 years. CASE REPORT A 77-year-old man was admitted in hospital for pernicious anemia. We discovered hypogammaglobulinemia with low levels of immunoglobulin G, A and M, but normal T-cell levels. We diagnosed common variable immunodeficiency. This patient had not had recurrent pyogenic infections.DISCUSSION:
This case shows that common variable immunodeficiency can be revealed late by an autoimmune disease. The pathogenesis of autoimmune diseases in this immunodeficiency remains unknown despite several possible explanations.
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Base de dados:
MEDLINE
Assunto principal:
Imunodeficiência de Variável Comum
/
Anemia Perniciosa
Tipo de estudo:
Etiology_studies
Limite:
Aged
/
Humans
/
Male
Idioma:
Fr
Ano de publicação:
1998
Tipo de documento:
Article