The transcriptional program of sporulation in budding yeast.
Science
; 282(5389): 699-705, 1998 Oct 23.
Article
em En
| MEDLINE
| ID: mdl-9784122
ABSTRACT
Diploid cells of budding yeast produce haploid cells through the developmental program of sporulation, which consists of meiosis and spore morphogenesis. DNA microarrays containing nearly every yeast gene were used to assay changes in gene expression during sporulation. At least seven distinct temporal patterns of induction were observed. The transcription factor Ndt80 appeared to be important for induction of a large group of genes at the end of meiotic prophase. Consensus sequences known or proposed to be responsible for temporal regulation could be identified solely from analysis of sequences of coordinately expressed genes. The temporal expression pattern provided clues to potential functions of hundreds of previously uncharacterized genes, some of which have vertebrate homologs that may function during gametogenesis.
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Base de dados:
MEDLINE
Assunto principal:
Saccharomyces cerevisiae
/
Esporos Fúngicos
/
Transcrição Gênica
/
Regulação Fúngica da Expressão Gênica
/
Proteínas de Saccharomyces cerevisiae
/
Proteínas de Ligação a DNA
/
Meiose
Tipo de estudo:
Prognostic_studies
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article