Lung cancer and arsenic exposure in drinking water: a case-control study in northern Chile.
Cad Saude Publica
; 14 Suppl 3: 193-8, 1998.
Article
em En
| MEDLINE
| ID: mdl-9819479
ABSTRACT
In some Chilean cities, levels of arsenic (As) in drinking water reached 800 (micrograms/L between 1950 and 1970, while current levels are 40 (micrograms/L. To evaluate the causal role of this exposure in lung and bladder cancers, we conducted a case-control study in Regions I, II, and III of the country. From 1994 to 1996, cases diagnosed as lung cancer and two hospital controls were entered in the study; one control was a patient with a cancer, while the other was a patient without cancer, both conditions unrelated to As. Controls were matched with cases by age and sex. A standard survey containing questions about residence, employment, health history, was administered to study subjects. Data on As concentrations in water were obtained from records of the municipal water companies. A total of 151 lung cancer cases and 419 controls (167 with cancer and 242 without cancer) were enrolled. Median level of lifetime As exposure was significantly higher among cases, with a clear dose-response relationship between mean As exposure levels, with an OR (95% CI) of 1, 1.7 (0.5-5.1), 3.9 (1.2-13.4), 5.5 (2.2-13.5), and 9.0 (3.6-22) for strata one to five respectively. This study provides new evidence that As in drinking water can cause internal cancers and gives an estimate of the form of this relationship.
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Base de dados:
MEDLINE
Assunto principal:
Arsênio
/
Poluentes Químicos da Água
/
Carcinógenos Ambientais
/
Exposição Ambiental
/
Neoplasias Pulmonares
Tipo de estudo:
Etiology_studies
/
Observational_studies
/
Risk_factors_studies
Limite:
Female
/
Humans
/
Male
País como assunto:
America do sul
/
Chile
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article