Cimetidine reduces weight and improves metabolic control in overweight patients with type 2 diabetes.
Int J Obes Relat Metab Disord
; 22(11): 1041-5, 1998 Nov.
Article
em En
| MEDLINE
| ID: mdl-9822940
ABSTRACT
OBJECTIVE:
To investigate the weight-reducing effect of cimetidine in overweight patients with Type 2 diabetes.DESIGN:
A 12-week clinical intervention study of 400 mg cimetidine prescribed three times daily in a randomised, double-blind, placebo-controlled design.SUBJECTS:
Forty-three overweight patients with Type 2 diabetes (age 18-65 y, body mass index (BMI) 27.2-48.2 kg/m2). MEASUREMENTS Body weight, BMI, body fat, waist and hip circumference, waist/hip ratio, blood pressure, fasting blood glucose, HbA1c, plasma concentrations of insulin, insulin/glucose ratio and lipids at the start and after 12 weeks, and daily recordings of appetite.RESULTS:
Subjects given cimetidine (n = 19) and placebo (n = 24) lost 5.0 +/- 2.2 kg (mean +/- s.d.) and 1.3 +/- 1.1 kg, respectively. Significant reductions were observed in appetite, body fat (29.9 +/- 6.6% to 25.3 +/- 7.4%), waist circumference (111.5 +/- 10.3 cm to 107.4 +/- 10.6 cm), waist/hip ratio (0.96 +/- 0.08 to 0.94 +/- 0.08), and systolic and diastolic blood pressure (reductions of 6.9 +/- 11.4 mm Hg and 6.0 +/- 6.6 mm Hg, respectively) in cimetidine group only. Significant decreases in fasting concentrations of blood glucose, HbA1c, plasma insulin, insulin/glucose ratio, plasma triglycerides and a significant increase in plasma high-density lipoprotein cholesterol were observed in the cimetidine group only.CONCLUSIONS:
Cimetidine reduces appetite and body weight, and improves metabolic control in overweight subjects with Type 2 diabetes.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Cimetidina
/
Diabetes Mellitus
/
Diabetes Mellitus Tipo 2
/
Antagonistas dos Receptores H2 da Histamina
/
Obesidade
Tipo de estudo:
Clinical_trials
Limite:
Adolescent
/
Adult
/
Female
/
Humans
/
Male
/
Middle aged
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article