Effects of ultrasound-assisted compaction on Ketoprofen/Eudragit S100 mixtures.
Eur J Pharm Sci
; 7(3): 207-13, 1999 Feb.
Article
em En
| MEDLINE
| ID: mdl-9845807
ABSTRACT
Ketoprofen alone and in binary mixtures with Eudragit S100 was compacted by an ultrasound-assisted (US) tableting machine at an energy ranging from 50 to 400 J. The final material was analysed by TLC and HPLC no decomposition product of the active agent was found. IR spectra and HSM revealed the absence of any interaction between the two components. Thermal analysis (DSC) evidenced that ketoprofen inside the mixtures was transformed into an amorphous state, documented by the decreasing of the DeltaHfus as the Eudragit/ketoprofen ratio increases and as US energy increases. While pure ketoprofen recovers its crystalline state quickly after the US treatment, the presence of Eudragit was found to slow down or possibly to prevent the regeneration of the crystallinity.
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Base de dados:
MEDLINE
Assunto principal:
Resinas Acrílicas
/
Anti-Inflamatórios não Esteroides
/
Cetoprofeno
/
Excipientes
Idioma:
En
Ano de publicação:
1999
Tipo de documento:
Article