New nonsteroidal androgen receptor modulators based on 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g] quinolinone.
Bioorg Med Chem Lett
; 8(7): 745-50, 1998 Apr 07.
Article
em En
| MEDLINE
| ID: mdl-9871534
ABSTRACT
A series of 2(1H)-pyrrolidino[3,2-g]quinolinones was prepared and tested for the ability to modulate the transcriptional activity of the human androgen receptor (hAR). The parent compound, 4-(trifluoromethyl)-2(1H)-pyrrolidino[3,2-g]quinolinone, displayed moderate interaction with hAR, but more substituted analogues, particularly 6,7-disubstituted compounds, were potent hAR agonists in vitro.
Buscar no Google
Base de dados:
MEDLINE
Assunto principal:
Pirrolidinas
/
Quinolinas
/
Transcrição Gênica
/
Receptores Androgênicos
/
Quinolonas
/
Antagonistas de Androgênios
Limite:
Animals
/
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article