Identification of a series of 1,2,3,4-tetrahydroisoquinolinyl-benzamides with potential anticonvulsant activity.
Bioorg Med Chem Lett
; 8(20): 2903-6, 1998 Oct 20.
Article
em En
| MEDLINE
| ID: mdl-9873645
ABSTRACT
A series of N-(tetrahydroisoquinolinyl)-2-methoxybenzamides was identified by high-throughput screening at the novel SB-204269 binding site. SAR studies have provided compounds 4 and 14 with high affinity and good anticonvulsant activity in animal models.
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Base de dados:
MEDLINE
Assunto principal:
Quinolinas
/
Benzamidas
/
Anticonvulsivantes
Tipo de estudo:
Diagnostic_studies
Limite:
Animals
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article