Nonpeptide oxytocin antagonists: potent, orally bioavailable analogs of L-371,257 containing a 1-R-(pyridyl)ethyl ether terminus.
Bioorg Med Chem Lett
; 8(21): 3081-6, 1998 Nov 03.
Article
em En
| MEDLINE
| ID: mdl-9873680
Structure-activity studies on the oxytocin antagonist 1 (L-371,257) have identified a new series of high affinity, receptor-selective OT antagonists in which the N-acetyl-4-piperidinyl ether terminus in 1 has been replaced with a 1-(aryl)ethoxy group.
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Base de dados:
MEDLINE
Assunto principal:
Oxazinas
/
Piperidinas
/
Ocitocina
Limite:
Animals
/
Female
/
Humans
Idioma:
En
Ano de publicação:
1998
Tipo de documento:
Article