Vitamin D metabolite-binding proteins in human tissue.
Biochim Biophys Acta
; 444(3): 921-5, 1976 Oct 22.
Article
em En
| MEDLINE
| ID: mdl-990280
Serum and post-microsomal supernatants of human lymphocyte, erythrocyte, skeletal muscle and parathyroid adenoma homogenates were examined for specific binding of 25-hydroxycholecalciferol (25-OHD3) and 1, 25-dihydroxycholecalciferol (1,25-(OH)2D3). Muscle, lymphocytes and parathyroid adenomata extracts contained a 6-S 25-OHD3-binding protein which was not found in erythrocyte extracts, and which was distinct from the smaller serum transport alpha-globulin. A cathodal, 1, 25-(OH)2D3-binding protein, which sedimented at 3-4 S was also detected in parathyroid tissue. These observations suggest the possibility of direct physiologic interaction between vitamin D metabolites and nucleated human tissues other than intestine and bone.
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Base de dados:
MEDLINE
Assunto principal:
Proteínas de Transporte
/
Di-Hidroxicolecalciferóis
/
Hidroxicolecalciferóis
Limite:
Humans
Idioma:
En
Ano de publicação:
1976
Tipo de documento:
Article