Changes in adrenal steroidogenesis in spontaneous bacterial peritonitis and sterile ascites
(East. Mediterr. health j).
em En
| WHOLIS
| ID: who-117558
Biblioteca responsável:
CH1.1
ABSTRACT
Adrenal androgens, particularly dehydroepiandrosterone [DHEA], may have important regulatory effects on the immune system in humans. This study measured the changes in adrenal steroidogenesis in 13 non-infected cirrhosis patients with sterile ascites and 13 patients with spontaneous bacterial peritonitis and the relation with circulating interleukin-6 [IL-6] levels. Comparisons were made with 10 healthy age-matched control subjects. The severity of bacterial peritonitis in liver cirrhosis was significantly associated with enhanced serum IL-6 and cortisol levels, and a decrease in serum DHEA sulfate in relation to serum IL-6 concentrations. Careful, long-term studies on DHEA administered to cirrhosis patients are needed to assess its safety in improving a number of pathological conditions that complicate liver cirrhosis
Palavras-chave
Texto completo:
1
Base de dados:
WHOLIS
Assunto principal:
Peritonite
/
Ascite
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Desidroepiandrosterona
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Medula Suprarrenal
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Androgênios
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Cirrose Hepática
Idioma:
En
Ano de publicação:
2008