Development of Acute Megakaryoblastic Leukemia with Isochromosome (12p) after a Primary Mediastinal Germ Cell Tumor in Korea
Journal of Korean Medical Science
; : 1099-1102, 2011.
Article
em En
| WPRIM
| ID: wpr-100569
Biblioteca responsável:
WPRO
ABSTRACT
The association of hematological malignancies with a mediastinal germ cell tumor (GCT) is very rare. We report one case of a young adult male with primary mediastinal GCT who subsequently developed acute megakaryoblastic leukemia involving isochromosome (12p). A 25-yr-old man had been diagnosed with a mediastinal GCT and underwent surgical resection and adjuvant chemotherapy. At 1 week after the last cycle of chemotherapy, his peripheral blood showed leukocytosis with blasts. A bone marrow study confirmed the acute megakaryoblastic leukemia. A cytogenetic study revealed a complex karyotype with i(12p). Although additional chemotherapy was administered, the patient could not attain remission and died of septic shock. This case was definitely distinct from therapy-related secondary leukemia in terms of clinical, morphologic, and cytogenetic features. To our knowledge, this is the first case report of a patient with mediastinal GCT subsequently developing acute megakaryoblastic leukemia involving i(12p) in Korea.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Choque Séptico
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Bleomicina
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Medula Óssea
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Cromossomos Humanos Par 12
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Protocolos de Quimioterapia Combinada Antineoplásica
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Leucemia Megacarioblástica Aguda
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Cisplatino
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Segunda Neoplasia Primária
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Neoplasias Embrionárias de Células Germinativas
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Isocromossomos
Limite:
Adult
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Humans
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Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article