Comprehensive geriatric assessment can predict the clinical outcomes of elderly patients with diffuse large B cell lymphoma in China / 中华血液学杂志
Chinese Journal of Hematology
; (12): 271-276, 2018.
Article
em Zh
| WPRIM
| ID: wpr-1011743
Biblioteca responsável:
WPRO
ABSTRACT
Objective: To validate comprehensive geriatric assessment (CGA) system in Chinese elderly diffuse large B cell lymphoma (DLBCL) patients. Methods: Patients ≥ 65 years of age who had been diagnosed with de novo DLBCL were screened for eligibility (n=99). CGA was performed during staging procedures through application of the following instruments: age, comorbidity score according to the Cumulative Illness Rating Score for Geriatrics(CIRS-G), activities of daily living (ADL), and instrumental activities of daily living (IADL). Results: All patients were classified as "ft" , "unfit" , and "frail" . Forty-nine (49.5%), 14 (14.1%), and 34 (36.4%) patients were categorized into the fit, unfit, and frail groups, respectively. The overall response rate was 91.8%, 64.3%, and 69.5% in fit, unfit, and frail group, respectively (χ(2)=9.311, P=0.007). Eleven (22.4%), 7 (50.0%), and 16(44.4%) patients showed disease relapse/progression in fit, unfit, and frail group, respectively (χ(2)=6.309, P=0.040). The 2-year probability of overall survival was 90.6%, 43.0%, and 58.5% in fit, unfit, and frail group, respectively (χ(2)=14.774, P=0.001). The 2-year probability of progression-free survival was 72.9%, 32.5%, and 37.3% in fit, unfit, and frail group, respectively (χ(2)=11.038, P=0.004). Conclusion: The CGA index can predict the clinical outcomes of elderly DLBCL patients in China.
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Base de dados:
WPRIM
Assunto principal:
Atividades Cotidianas
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Protocolos de Quimioterapia Combinada Antineoplásica
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Avaliação Geriátrica
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China
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Linfoma Difuso de Grandes Células B
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Resultado do Tratamento
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Recidiva Local de Neoplasia
Limite:
Aged
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Humans
País como assunto:
Asia
Idioma:
Zh
Ano de publicação:
2018
Tipo de documento:
Article