Research progress of B lymphocytes in non-infectious uveitis / 国际眼科杂志(Guoji Yanke Zazhi)
International Eye Science
; (12): 718-722, 2024.
Article
em Zh
| WPRIM
| ID: wpr-1016583
Biblioteca responsável:
WPRO
ABSTRACT
Non-infectious uveitis, an autoimmune disease that can cause severe visual impairment, can be difficult to treat. According to the prevailing hypothesis, the immune-mediated imbalance that contributes to non-infectious uveitis is primarily driven by CD4+T cells. However, recent research has shown that B cells also play a significant role in this process, participating in various ways such as antibody production, antigen presentation, and cytokine secretion in both human uveitis and experimental autoimmune uveitis models. Therapies targeting B cells have been used extensively in various autoimmune diseases. Rituximab, a B-cell inhibitor, is effective in treating noninfectious uveitis that is unresponsive to conventional corticosteroid and immunosuppressive therapy. This paper provides an overview of the involvement of B cells in non-infectious uveitis and their potential use in cellular therapies, aiming to further investigate the mechanisms and develop more effective strategies for prevention and treatment.
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Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article