Relationship between Preoperative FAR and Pathological Features of Pancreatic Head Carcinoma and Prognosis Influencing Factors / 医学研究杂志

ABSTRACT

Objective To analyze the relationship between preoperative fibrinogen to albumin ratio(FAR)and pathological features of pancreatic head carcinoma and prognosis influencing factors.Methods The clinical data of 92 patients with pancreatic head carcinoma who underwent radical pancreaticoduodenectomy in the Second Affiliated Hospital of Kunming Medical University from January 2016 to De-cember 2018 were retrospectively analyzed.Receiver operator characteristic(ROC)curve was used to determine the optimal cut-off value of preoperative FAR level.COX proportional risk regression model was used to analyze the independent risk factors of pancreatic head car-cinoma,and Kaplan-Meier method was used to draw the survival curve.Results Univariate analysis of COX proportional risk regression model showed that preoperative high FAR,high carbohydrate antigen 19-9(Ca19-9),lymph node metastasis,high TNM stage,low differentiation and maximum tumor diameter ≥4cm were associated with poor prognosis in patients with pancreatic head carcinoma.Multi-variate analysis showed that high Ca19-9,preoperative high FAR,high TNM stage and low differentiation were independent risk factors for the prognosis of patients with pancreatic head carcinoma.Kaplan-Meier survival analysis showed that the survival rates of patients in the low FAR group were 68.3％and 37.5％in the first year and the third year,respectively;and those in the high FAR group were 32.4％and 3.1％,respectively.The mean survival time and median survival time of patients in the low FAR group were significantly bet-ter those in the high FAR group(24.4months vs 9.7months,17.0months vs 8.0months),and the differences were statistically significant(P＜0.05).Conclusion Preoperative FAR can effectively predict the prognosis of patients with pancreatic head cancer.Patients with high Ca19-9,high preoperative FAR,high TNM stage and low differentiation have worse prognosis and shorter survival time.