New research direction of organ dysfunction caused by hemorrhagic shock: mechanisms of mitochondrial quality control / 中华危重病急救医学
Chinese Critical Care Medicine
; (12): 93-97, 2024.
Article
em Zh
| WPRIM
| ID: wpr-1025354
Biblioteca responsável:
WPRO
ABSTRACT
Hemorrhagic shock (HS) is one of the leading causes of death among young adults worldwide. Multiple organ dysfunction in HS is caused by an imbalance between tissue oxygen supply and demand, which is closely related to the poor prognosis of patient. Mitochondrial dysfunction is one of the key mechanisms contributing to multiple organ dysfunction in HS, while mitochondrial quality control regulates mitochondrial function through a series of processes, including mitochondrial biogenesis, mitochondrial dynamics, mitophagy, mitochondrial-derived vesicles, and mitochondrial protein homeostasis. Modulating mitochondrial quality control can improve organ dysfunction. This review aims to summarize the effects of mitochondrial dysfunction on organ function in HS and discuss the potential mechanisms of mitochondrial quality control, providing insights into the injury mechanisms underlying HS and guiding clinical management.
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Base de dados:
WPRIM
Idioma:
Zh
Ano de publicação:
2024
Tipo de documento:
Article