Phenotype of peroxisome proliferator-activated receptor-alpha(PPARalpha)deficient mice on mixed background fed high fat diet
Journal of Veterinary Science
; : 239-244, 2003.
Article
em En
| WPRIM
| ID: wpr-103635
Biblioteca responsável:
WPRO
ABSTRACT
Considerable controversy exists in determining the role of peroxisome proliferator-activated receptor-alpha(PPARalpha) on obesity. Previous reports demonstrated that PPARalpha is a critical modulator of lipid homeostasis, but the overt, obese phenotypic characterization in the strain of PPAR deficient (PPARalpha-/-) mice is influenced by other factors, including diet and genetics. Therefore, it is necessary to establish the phenotypic characterization of PPARalpha-/- mice prior to the obesity-related study. In this study, we observed phenotype of PPARalpha-/- mice on mixed genetic background (C57BL/6Nx129/Sv) fed a high fat diet for 16 weeks. PPARalpha-/- mice, regardless of sex, raised body growth rate significantly comparing with wild type and showed male-specific fatty change in the liver. They were shown to lack hepatic induction of PPARalpha target genes encoding enzymes for fatty acid beta-oxidation.
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Base de dados:
WPRIM
Assunto principal:
Fenótipo
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Fatores de Transcrição
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Triglicerídeos
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Peso Corporal
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RNA
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Gorduras na Dieta
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Tecido Adiposo
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Colesterol
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Organismos Livres de Patógenos Específicos
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Receptores Citoplasmáticos e Nucleares
Limite:
Animals
Idioma:
En
Ano de publicação:
2003
Tipo de documento:
Article