To explore the correlation analysis between the changes of cognitive function and the expression levels of serum ICAM-1 and 8-iso-PGF2α in patients with acute ischemic stroke / 中风与神经疾病杂志

ABSTRACT

@#To explore the correlation analysis between the changes of cognitive function and the expression levels of serum ICAM-1 and 8-iso-PGF2α in patients with acute ischemic stroke. Method A total of 100 patients with Acute ischemic stroke admitted to our hospital from August 2017 to October 2019 were divided into group A （60 cases，MoCA score<26 points） and group B （40 cases，MoCA） according to the MoCA score Score ≥26 points）. Enzyme-linked immunosorbent assay was used to determine the expression levels of ICAM-1 and 8-iso-PGF2α in the two groups. Spearman was used to analyze the correlation between serum ICAM-1 and 8-iso-PGF2α and MoCA scores. Logistic regression was used to analyze Acute ischemic stroke. Influencing factors of patients’ cognitive function changes. ROC curve analysis of serum ICAM-1，8-iso-PGF2α expression for the diagnostic value of cognitive function in patients with Acute ischemic stroke. Results The expression of serum ICAM-1 and 8-iso-PGF2α in group A was significantly higher than that in group B （P<0.05）；Serum ICAM-1 and 8-iso-PGF2α expression levels were significantly correlated with the location of infarct，carotid atherosclerosis，carotid stenosis，NIHSS score，MoCA，and age （P<0.05），but not related to education level （P> 0.05）. The infarcts were located in the thalamus，temporal lobe and frontal lobe. NIHSS score，diabetes and hypertension were independent risk factors for cognitive dysfunction in patients with Acute ischemic stroke （P<0.05）. The sensitivity and specificity of ICAM-1 and 8-iso-PGF2α in diagnosing the changes of cognitive function in patients with Acute ischemic stroke were 93.00% and 90.00% （P<0.05）. Conclusion The expression of serum ICAM-1 and 8-iso-PGF2α is closely related to the changes of cognitive function in patients with Acute ischemic stroke.