No association of prion protein gene polymorphisms with Alzheimer's disease in Korean population
Experimental & Molecular Medicine
; : 727-731, 2006.
Article
em En
| WPRIM
| ID: wpr-106412
Biblioteca responsável:
WPRO
ABSTRACT
The polymorphism at codon 129 (M129V) of the human prion protein gene (PRNP) is a known risk factor for Creutzfeldt-Jakob disease (CJD) in Caucasians. There are few reports of this polymorphism's effect on memory and on the risk of Alzheimer's disease (AD). The M129V genotype distributions among Asians are very different from Caucasians. Another polymorphism, codon 219 (E219K) is not found in Caucasians. We investigated two polymorphisms of PRNP, M129V (rs1799990) and E219K (rs1800014) in 297 Korean AD patients and 217 healthy subjects. The analysis of the genotype and allele distributions showed no significant difference between the AD patients and the controls in both polymorphisms (P=0.19 genotype, P=0.51 allele for M129V; P=0.64 genotype, P=0.50 allele for E219K). Also, the PRNP polymorphisms were not significantly associated with AD when the populations were stratified for the presence or absence of apolipoprotein E-e4 (ApoE-epsilon4) allele. These results suggest that the PRNP genetic variants are not associated with the risk for AD in Korean population.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Apolipoproteínas E
/
Polimorfismo Genético
/
Príons
/
Códon
/
Predisposição Genética para Doença
/
Alelos
/
Doença de Alzheimer
/
Genótipo
/
Coreia (Geográfico)
Tipo de estudo:
Risk_factors_studies
Limite:
Aged
/
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2006
Tipo de documento:
Article