A Case of ACTH-producing Pancreatic Neuroendocrine Tumor Presenting with Cushing Syndrome
Soonchunhyang Medical Science
; : 159-162, 2012.
Article
em Ko
| WPRIM
| ID: wpr-110151
Biblioteca responsável:
WPRO
ABSTRACT
Pancreatic neuroendocrine tumors are rare neoplasm arising from pancreatic islet cells. Occasionally they are functioning tumors secreting a variety of hormones such as insulin, gastrin, glucagon, and vasoactive intestinal peptides. Adrenocorticotropic hormone (ACTH) secreting pancreatic neuroendocrine tumors (ACTHomas) are very rare and there have been about 110 case reports worldwide. Due to excessive ectopic ACTH production and resulting hypercortisolemia, patients with ACTHoma usually present with Cushing syndrome. ACTHomas have a poor prognosis with severe and rapidly progressive clinical courses. They often present with unresectable liver metastases and there remains little consensus on its standard treatment. We report a 55-year-old female with ACTH-producing pancreatic neuroendocrine tumor, who was treated with surgical resection of pancreatic tail, spleen, and a portion of stomach. Sixteen months later, abdomen computed tomography scan showed multiple liver metastases, which were treated with transarterial chemoembolization.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Peptídeos
/
Prognóstico
/
Baço
/
Estômago
/
Gastrinas
/
Glucagon
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Ilhotas Pancreáticas
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Tumores Neuroendócrinos
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Hormônio Adrenocorticotrópico
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Síndrome de Cushing
Tipo de estudo:
Guideline
/
Prognostic_studies
Limite:
Female
/
Humans
Idioma:
Ko
Ano de publicação:
2012
Tipo de documento:
Article