Two Cases of Anti-Glomerular Basement Membrane Antibody Disease Associated with Perinuclear-Anti-Neutrophil Cytoplasmic Antibody / 대한내과학회지
Korean Journal of Medicine
; : 514-519, 2012.
Article
em Ko
| WPRIM
| ID: wpr-12477
Biblioteca responsável:
WPRO
ABSTRACT
Anti-glomerular basement membrane antibody (anti-GBM Ab) disease is characterized by circulating antibodies to the glomerular basement membrane and the deposition of IgG or, rarely, IgA along the glomerular basement membrane. This disease accounts for 10-20% of crescentic glomerulonephritis. We report two patients with anti-GBM Ab disease who were positive for perinuclear-anti-neutrophil cytoplasmic antibody (p-ANCA). Percutaneous renal biopsies showed many crescent formations and linear deposits of IgG along the glomerular basement membrane. Serologic tests for p-ANCA were positive. They were treated with steroid pulse and cyclophosphamide and one patient also underwent plasma exchange therapy. Despite immunosuppressive therapy, their renal functions did not improve and both required regular hemodialysis.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Troca Plasmática
/
Autoanticorpos
/
Membrana Basal
/
Biópsia
/
Imunoglobulina A
/
Imunoglobulina G
/
Testes Sorológicos
/
Diálise Renal
/
Anticorpos Anticitoplasma de Neutrófilos
/
Ciclofosfamida
Tipo de estudo:
Diagnostic_studies
Limite:
Humans
Idioma:
Ko
Ano de publicação:
2012
Tipo de documento:
Article