The Study of Toxicity of Mitomycin C and Steroid as Eyedrops in Rabbit Cornea
Journal of the Korean Ophthalmological Society
; : 543-549, 2000.
Article
em Ko
| WPRIM
| ID: wpr-130109
Biblioteca responsável:
WPRO
ABSTRACT
To investigate the drug effect of topical Mitomycin C in various concentrations combined with steroid, we used 30 rabbits whose corneal epitheliums were abraded intentionally. They were divided into 5 groups. Using MMC in various concentrations and steroids, we instilled them into right eyes and saline into left eyes as control. We measured the healing rate at a interval of 12 hours. Three months later, we sacrificed one of them and examined the pathological changes from various ocular tissues. We found many complications such as corneal edema, ulcer, opacity and definite delay of wound healing when the concentration higher than 0.04%MMC was used. There were also decreased fibroblast cells in H-E staining. The steroids seemed not to pose any influence on the effect of MMC. In conclusion, we must take the great care in the use of MMC, and the concentration should be low when used. In addition, we still think there ought to be more studies as to the effect of steroids according to MMC levels.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Soluções Oftálmicas
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Esteroides
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Úlcera
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Cicatrização
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Edema da Córnea
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Mitomicina
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Epitélio Corneano
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Córnea
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Intenção
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Fibroblastos
Limite:
Animals
Idioma:
Ko
Ano de publicação:
2000
Tipo de documento:
Article