Characteristics and Follow-up Results of the Window Period Blood Donors for Hepatitis C Virus / 대한수혈학회지
Korean Journal of Blood Transfusion
; : 15-22, 2007.
Article
em Ko
| WPRIM
| ID: wpr-14269
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: To improve the safety of the blood supply in Korea, nucleic acid amplification testing (NAT) for HCV and HIV-1 as a blood screening test has been used by the Korean Red Cross since February 1st, 2005. Until October 31st 2006, a total of 4,037,618 donor samples had been tested and 436 cases showed reactivity for HCV RNA. Only 10 of these cases showed serologically negative antibody results. METHODS: We investigated the characteristics and the follow-up results of the ten donors who showed HCV RNA reactivity and serologically negative results. RESULTS: All the ten donors were identified to be "window period" blood donors with confirmation of their seroconversion by follow-up testing. The average RNA titer of the donors was 9.21x106 IU/mL. Five donors showed high levels of ALT. One donor showed the reversed pattern on the test results for antibody and RNA. CONCLUSION: By detecting five cases of HCV "window period" infection, NAT has increased the safety of the Korean blood supply. But it is considered that NAT can not be a substitute serological test and an adequate follow-up strategy is required for verification of the accurate seroconversion time.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Cruz Vermelha
/
Doadores de Tecidos
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Doadores de Sangue
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RNA
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Testes Sorológicos
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Programas de Rastreamento
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Seguimentos
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HIV-1
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Hepatite C
/
Hepacivirus
Tipo de estudo:
Diagnostic_studies
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Observational_studies
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Prognostic_studies
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Screening_studies
Limite:
Humans
País como assunto:
Asia
Idioma:
Ko
Ano de publicação:
2007
Tipo de documento:
Article