Increased Sclerostin Levels after Further Ablation of Remnant Estrogen by Aromatase Inhibitors
Endocrinology and Metabolism
; : 58-64, 2015.
Article
em En
| WPRIM
| ID: wpr-150118
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Sclerostin is a secreted Wnt inhibitor produced almost exclusively by osteocytes, which inhibits bone formation. Aromatase inhibitors (AIs), which reduce the conversion of steroids to estrogen, are used to treat endocrine-responsive breast cancer. As AIs lower estrogen levels, they increase bone turnover and lower bone mass. We analyzed changes in serum sclerostin levels in Korean women with breast cancer who were treated with an AI. METHODS: We included postmenopausal women with endocrine-responsive breast cancer (n=90; mean age, 57.7 years) treated with an AI, and compared them to healthy premenopausal women (n=36; mean age, 28.0 years). The subjects were randomly assigned to take either 5 mg alendronate with 0.5 microg calcitriol (n=46), or placebo (n=44) for 6 months. RESULTS: Postmenopausal women with breast cancer had significantly higher sclerostin levels compared to those in premenopausal women (27.8+/-13.6 pmol/L vs. 23.1+/-4.8 pmol/L, P0.05). CONCLUSION: Serum sclerostin levels increased with absolute deficiency of residual estrogens in postmenopausal women with endocrine-responsive breast cancer who underwent AI therapy with concurrent bone loss.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Osteócitos
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Osteogênese
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Osteoporose
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Coluna Vertebral
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Esteroides
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Neoplasias da Mama
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Calcitriol
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Densidade Óssea
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Alendronato
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Inibidores da Aromatase
Tipo de estudo:
Clinical_trials
Limite:
Female
/
Humans
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article