Relationship of Vascular Factors on Electrophysiologic Severity of Diabetic Neuropathy
Annals of Rehabilitation Medicine
; : 56-65, 2016.
Article
em En
| WPRIM
| ID: wpr-16126
Biblioteca responsável:
WPRO
ABSTRACT
OBJECTIVE:
To investigate the impact of vascular factors on the electrophysiologic severity of diabetic neuropathy (DPN).METHODS:
Total 530 patients with type 2 diabetes were enrolled retrospectively. We rated severity of DPN from 1 (normal) to 4 (severe) based on electrophysiologic findings. We collected the data concerning vascular factors (including brachial-ankle pulse wave velocity [PWV], ankle brachial index, ultrasound of carotid artery, lipid profile from the blood test, and microalbuminuria [MU] within 24 hours urine), and metabolic factors of diabetes (such as glycated hemoglobin [HbA1c]). We analyzed the differences among the four subgroups using χ2 test and ANOVA, and ordinal logistic regression analysis was performed to investigate the relationship between significant variables and severity of DPN.RESULTS:
The severity of DPN was significantly associated with duration of diabetes, HbA1c, existence of diabetic retinopathy and nephropathy, PWV, presence of plaque, low density lipoprotein-cholesterol and MU (p<0.05). Among these variables, HbA1c and presence of plaque were more significantly related with severity of DPN in logistic regression analysis (p<0.001), and presence of plaque showed the highest odds ratio (OR=2.52).CONCLUSION:
Our results suggest that markers for vascular wall properties, such as PWV and presence of plaque, are significantly associated with the severity of DPN. The presence of plaque was more strongly associated with the severity of DPN than other variables.Palavras-chave
Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Hemoglobinas Glicadas
/
Artérias Carótidas
/
Modelos Logísticos
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Razão de Chances
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Estudos Retrospectivos
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Ultrassonografia
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Estenose das Carótidas
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Angiopatias Diabéticas
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Neuropatias Diabéticas
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Retinopatia Diabética
Tipo de estudo:
Diagnostic_studies
/
Etiology_studies
/
Observational_studies
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Prognostic_studies
/
Risk_factors_studies
Limite:
Humans
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article