Diabetes-Related Cardiac Dysfunction
Endocrinology and Metabolism
; : 171-179, 2017.
Article
em En
| WPRIM
| ID: wpr-161480
Biblioteca responsável:
WPRO
ABSTRACT
The proposal that diabetes plays a role in the development of heart failure is supported by the increased risk associated with this disease, even after correcting for all other known risk factors. However, the precise mechanisms contributing to the condition referred to as diabetic cardiomyopathy have remained elusive, as does defining the disease itself. Decades of study have defined numerous potential factors that each contribute to disease susceptibility, progression, and severity. Many recent detailed reviews have been published on mechanisms involving insulin resistance, dysregulation of microRNAs, and increased reactive oxygen species, as well as causes including both modifiable and non-modifiable risk factors. As such, the focus of the current review is to highlight aspects of each of these topics and to provide specific examples of recent advances in each area.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Estresse Fisiológico
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Resistência à Insulina
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Fatores de Risco
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Espécies Reativas de Oxigênio
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MicroRNAs
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Suscetibilidade a Doenças
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Metabolismo Energético
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Cardiomiopatias Diabéticas
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Insuficiência Cardíaca
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Doenças Metabólicas
Tipo de estudo:
Etiology_studies
/
Risk_factors_studies
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article