Association of a Missense ALDH2 Single Nucleotide Polymorphism (Glu504Lys) With Benign Prostate Hyperplasia in a Korean Population / 대한배뇨장애요실금학회지
International Neurourology Journal
; : 168-173, 2013.
Article
em En
| WPRIM
| ID: wpr-166294
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: Aldehyde dehydrogenase 2 (ALDH2) is a well-known gene involved in alcohol and aldehyde metabolism. Moreover, recent studies have reported associations between ALDH2 and age-related disorders. Benign prostate hyperplasia (BPH) is an age-related disorder and genetic factors may contribute to its onset. In this study, we investigated the association of a well-studied ALDH2 single nucleotide polymorphism (SNP), rs671, with the onset and clinical features of BPH. METHODS: A total of 222 BPH patients and 214 control subjects were genotyped. The clinical features of the BPH patients (prostate volume, prostate-specific antigen level, and International Prostatic Symptom Score) were analyzed. RESULTS: The results show that rs671 was only associated with the volume of BPH in genotype and allele frequencies (P<0.05). CONCLUSION: We propose that rs671 is an Asian-specific SNP in ALDH2 that may affect the disease progression of BPH in the Korean population.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Próstata
/
Hiperplasia Prostática
/
Antígeno Prostático Específico
/
Progressão da Doença
/
Polimorfismo de Nucleotídeo Único
/
Aldeído Desidrogenase
/
Frequência do Gene
/
Genótipo
/
Hiperplasia
/
Metabolismo
Limite:
Humans
Idioma:
En
Ano de publicação:
2013
Tipo de documento:
Article