Improvement of Pulmonary Function after Administration of Azithromycin in a Patient with Bronchiolitis Obliterans: a Case Report / 결핵및호흡기질환
Tuberculosis and Respiratory Diseases
; : 410-415, 2008.
Article
em Ko
| WPRIM
| ID: wpr-168138
Biblioteca responsável:
WPRO
ABSTRACT
Bronchiolitis obliterans (BO) is a serious noninfectious complication following an allogeneic bone marrow transplant (BMT). A 21-year-old female received an allogeneic BMT as a treatment for myelodyplastic syndrome. Four months after the BMT, progressive dyspnea developed and BO was also diagnosed by a lung biopsy. The patient was administered steroid and immunosuppressive agents for 1 year but there was no improvement in pulmonary function. Azithromycin was prescribed (500 mg q.d. for 3 days followed by 250 mg three time a week) because macrolides might decrease the inflammatory reaction leading to BO. The patient's pulmonary function improved after administration of azithromycin for 1 year. The forced expiratory volume in a one second (FEV1) increase was 220 mL (28.2%) and the forced vital capacity (FVC) increase was 460 mL (25.7%). We report the improvement in the pulmonary function after the administration of azithromycin for 1 year in a patient with BO after a BMT.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Biópsia
/
Medula Óssea
/
Bronquiolite
/
Bronquiolite Obliterante
/
Capacidade Vital
/
Volume Expiratório Forçado
/
Transplante de Medula Óssea
/
Azitromicina
/
Macrolídeos
/
Transplantes
Limite:
Female
/
Humans
Idioma:
Ko
Ano de publicação:
2008
Tipo de documento:
Article