Maturation of bone marrow-derived dendritic cells by a novel beta-glucan purified from Paenibacillus polymyxa JB115
Journal of Veterinary Science
; : 187-189, 2011.
Article
em En
| WPRIM
| ID: wpr-189394
Biblioteca responsável:
WPRO
ABSTRACT
We investigated the immunostimulatory effects of a novel beta-glucan purified from Paenibacillus (P.) polymyxa JB115 on bone marrow-derived dendritic cells (DCs), a type of potent antigen-presenting cells. beta-glucan isolated from P. polymyxa JB115 enhanced the viability and induced the maturation of DCs. beta-glucan markedly increased the cytokine production of DCs and surface expression of DC markers. In addition, DCs treated with beta-glucan showed a higher capacity to stimulate allogeneic spleen cell proliferation compared to those treated with medium alone. These results demonstrate the effect of beta-glucan on DC maturation and may increase the use of beta-glucan.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Células Dendríticas
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Células da Medula Óssea
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Sobrevivência Celular
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Imunofenotipagem
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Fator de Necrose Tumoral alfa
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Interleucina-12
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Beta-Glucanas
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Paenibacillus
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Citometria de Fluxo
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Camundongos Endogâmicos BALB C
Limite:
Animals
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article