The Role of Macrophage Lipophagy in Reverse Cholesterol Transport
Endocrinology and Metabolism
; : 41-46, 2017.
Article
em En
| WPRIM
| ID: wpr-194432
Biblioteca responsável:
WPRO
ABSTRACT
Macrophage cholesterol efflux is a central step in reverse cholesterol transport, which helps to maintain cholesterol homeostasis and to reduce atherosclerosis. Lipophagy has recently been identified as a new step in cholesterol ester hydrolysis that regulates cholesterol efflux, since it mobilizes cholesterol from lipid droplets of macrophages via autophagy and lysosomes. In this review, we briefly discuss recent advances regarding the mechanisms of the cholesterol efflux pathway in macrophage foam cells, and present lipophagy as a therapeutic target in the treatment of atherosclerosis.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Autofagia
/
Colesterol
/
Aterosclerose
/
Gotículas Lipídicas
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Células Espumosas
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Homeostase
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Hidrólise
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Lisossomos
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Macrófagos
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article