Infliximab Treatment for Refractory Kawasaki Disease in Korean Children
Korean Circulation Journal
; : 334-338, 2010.
Article
em En
| WPRIM
| ID: wpr-196628
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND AND OBJECTIVES: This was a multicenter study to evaluate the usefulness of the tumor necrosis factor-alpha (TNF-alpha) blocker infliximab for treatment of Korean pediatric patients with refractory Kawasaki disease (KD). SUBJECTS AND METHODS: Data from 16 patients throughout Korea who were diagnosed with refractory KD and received infliximab were collected retrospectively. RESULTS: Complete response to therapy with cessation of fever occurred in 13 of 16 patients. C-reactive protein (CRP) concentrations decreased following infliximab infusion in all 14 patients in whom it was measured before and after treatment. There were no infusion reactions or complications associated with infliximab except in 1 case with acute hepatitis occurring during treatment followed by calculous cholecystitis 4 months later. Fifteen patients had coronary artery (CA) abnormalities before infliximab therapy. Three had transient mild dilatation and 9 had CA aneurysms, with subsequent normalization in 4 patients, persistent mild dilatation in 3, persistent aneurysm in 2, and there were 3 cases (2 with CA aneurysm, 1 with mild CA dilatation) without follow-up echocardiography. CONCLUSION: The results of this study suggest that infliximab may be useful in the treatment of refractory KD, and it appears that there is no significant further progression of CA lesions developing after infliximab treatment. Multicenter trials with larger numbers of patients and long-term follow-up are necessary to assess the clinical efficacy and safety of infliximab in refractory KD.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Proteína C-Reativa
/
Ecocardiografia
/
Colecistite
/
Estudos Retrospectivos
/
Seguimentos
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Fator de Necrose Tumoral alfa
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Vasos Coronários
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Dilatação
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Febre
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Infliximab
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Child
/
Humans
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2010
Tipo de documento:
Article