Elevated serum immunoglobulin E level as a marker for progression of immunoglobulin A nephropathy
Kidney Research and Clinical Practice
; : 147-151, 2016.
Article
em En
| WPRIM
| ID: wpr-198731
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND: Immunoglobulin E (IgE) has traditionally been associated with anaphylaxis and atopic disease. Previous studies reported that serum IgE levels are elevated in nephrotic syndrome and suggested IgE levels as a prognostic indicator in glomerular diseases. The aim of this study was to explore the association between serum IgE levels and renal outcome in patients with immunoglobulin A nephropathy (IgAN). METHODS: We included 117 patients with biopsy-proven IgAN. Renal progression was defined if a patient meets one of these criteria: (1) a negative value of delta estimated glomerular filtration rate (mL/min/1.73 m²/mo) or (2) a rise in serum creatinine to an absolute level of ≥ 1.3 mg/dL (male) or 1.2 mg/dL (female). We defined delta changes in serum creatinine, estimated glomerular filtration rate, and proteinuria as a difference of values during the follow-up period. RESULTS: A total of 117 patients with IgAN were included. The serum IgE level was significantly high in the renal progressive group compared with the nonprogressive group. Sex and history of gross hematuria were significantly different between the high-IgE group and the low-IgE group. Regression analysis showed that a male sex, initial proteinuria, and change of proteinuria were significantly associated with serum IgE levels. CONCLUSION: The serum IgE level is potentially associated with disease progression and pathogenesis of IgAN.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Proteinúria
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Imunoglobulina A
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Imunoglobulina E
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Imunoglobulinas
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Seguimentos
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Progressão da Doença
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Creatinina
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Taxa de Filtração Glomerular
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Glomerulonefrite
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Glomerulonefrite por IGA
Tipo de estudo:
Observational_studies
/
Prognostic_studies
Limite:
Humans
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Male
Idioma:
En
Ano de publicação:
2016
Tipo de documento:
Article