Thrombotic Microangiopathy during Ganciclovir Treatment for Cytomegalovirus Infection in a Patient with Autologous Hematopoietic Stem Cell Transplantation / 임상소아혈액종양
Clinical Pediatric Hematology-Oncology
; : 161-164, 2011.
Article
em En
| WPRIM
| ID: wpr-201476
Biblioteca responsável:
WPRO
ABSTRACT
Thrombotic microangiopathy (TMA) is a known complication of hematopoietic stem cell transplantation (HSCT). Here, we describe a case of TMA after autologous HSCT, which was associated with ganciclovir treatment. A 5-year-old boy presented with Coombs-negative hemolytic anemia, thrombocytopenia, gross hematuria, massive proteinuria, and hypertension during ganciclovir treatment after autologous HSCT. TMA was confirmed by renal biopsy which showed swelling of endothelial cells, occlusion of the glomerular lumina, duplication of glomerular basement membranes, and mesangiolysis. There was complete resolution of TMA in both laboratory and clinical manifestations after ganciclovir cessation only with supportive cares and hydration.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Proteinúria
/
Trombocitopenia
/
Biópsia
/
Células-Tronco Hematopoéticas
/
Ganciclovir
/
Pré-Escolar
/
Infecções por Citomegalovirus
/
Transplante de Células-Tronco Hematopoéticas
/
Citomegalovirus
/
Células Endoteliais
Limite:
Humans
Idioma:
En
Ano de publicação:
2011
Tipo de documento:
Article