Neuroprotective Effect of Fucoidan against N-methyl-D-aspartate-Induced Excitotoxicity in Rat Hippocampus
Experimental Neurobiology
; : 123-128, 2009.
Article
em En
| WPRIM
| ID: wpr-202565
Biblioteca responsável:
WPRO
ABSTRACT
Fucoidan, a sulfated polyanionic polymer of L-fucose, is obtained from brown marine macroalgae. In the present study, neuroprotective effect of fucoidan against N-methyl- D-aspartate (NMDA)-induced excitotoxicity in the hippocampus was investigated. The patch clamp study revealed that fucoidan significantly inhibited NMDA receptor-activated ion current in the acutely dissociated hippocampal CA1 neurons. In an organotypic hippocampal slice culture, fucoidan inhibited NMDA-induced neuronal cell death in a dose-dependent manner. The present study showed that fucoidan possesses a neuroprotective effect against NMDA-induced excitotoxicity, and that the suppressive effect of fucoidan on the NMDA-induced ion current can be suggested as being the underlying neuroprotective mechanism of fucoidan.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Polímeros
/
Polissacarídeos
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Alga Marinha
/
N-Metilaspartato
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Morte Celular
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Fármacos Neuroprotetores
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Ácido D-Aspártico
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Hipocampo
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Neurônios
Limite:
Animals
Idioma:
En
Ano de publicação:
2009
Tipo de documento:
Article