Effect of xanthohumol on melanogenesis in B16 melanoma cells
Experimental & Molecular Medicine
; : 313-319, 2008.
Article
em En
| WPRIM
| ID: wpr-205425
Biblioteca responsável:
WPRO
ABSTRACT
Xanthohumol (XH), the principal prenylflavonoid of the hop plant (Humulus lupulus L.), dose-dependently inhibited isobutylmethylxanthine (IBMX)-induced melanogenesis in B16 melanoma cells, with little cytotoxicity at the effective concentrations. Decreased melanin content was accompanied by reduced tyrosinase enzyme activity, protein and mRNA expression. The levels of tyrosinase-related protein 1 and 2 mRNAs were decreased by XH. XH also inhibited alpha-melanocyte stimulating hormone- or forskolin-induced increases in melanogenesis, suggesting an action on the cAMP-dependent melanogenic pathway. XH downregulated the protein and mRNA expression of microphthalmia-associated transcription factor (MITF), a master transcriptional regulator of key melanogenic enzymes. These results suggest that XH might act as a hypo-pigmenting agent through the downregulation of MITF in the cAMP-dependent melanogenic pathway.
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Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Oxirredutases
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Propiofenonas
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Melanoma Experimental
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Colforsina
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Alfa-MSH
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Glicoproteínas de Membrana
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Transdução de Sinais
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Regulação para Baixo
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Linhagem Celular
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Sobrevivência Celular
Limite:
Animals
Idioma:
En
Ano de publicação:
2008
Tipo de documento:
Article