Association of nasal inflammation and lower airway responsiveness in schoolchildren based on an epidemiological survey
The Korean Journal of Internal Medicine
; : 226-231, 2015.
Article
em En
| WPRIM
| ID: wpr-214109
Biblioteca responsável:
WPRO
ABSTRACT
BACKGROUND/AIMS: We sought to increase our understanding of the rhinitis-asthma relationship and improve strategies for the treatment of patients with these diseases. The aim of this study was to identify a connection between upper airway inflammation and lower airway responsiveness. METHODS: We counted eosinophils on nasal smears, and performed spirometry, allergic skin tests, and methacholine challenge tests in 308 schoolchildren plus a questionnaire on respiratory symptoms. The methacholine concentration causing a 20% fall in forced expiratory volume in 1 second (PC20 0.05). No difference in BHR was detected when comparing subjects with and without nasal eosinophils. There were significant differences in the PC20 between subjects with greater than 50% nasal eosinophils and without nasal eosinophils (11.01 +/- 2.92 mg/mL vs. 17.38 +/- 0.61 mg/mL; p < 0.001). CONCLUSIONS: These findings demonstrated that nasal eosinophilic inflammation might contribute to lower airway responsiveness in schoolchildren, based on an epidemiological survey.
Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Asma
/
Espirometria
/
Testes de Provocação Brônquica
/
Testes Intradérmicos
/
Rinite
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Inquéritos e Questionários
/
Inquéritos Epidemiológicos
/
Fatores Etários
/
Hiper-Reatividade Brônquica
/
Distribuição por Idade
Tipo de estudo:
Prognostic_studies
Limite:
Adolescent
/
Child
/
Female
/
Humans
/
Male
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2015
Tipo de documento:
Article