Administration of Goji (Lycium chinense Mill.) Extracts Improves Erectile Function in Old Aged Rat Model
The World Journal of Men's Health
; : 43-50, 2017.
Article
em En
| WPRIM
| ID: wpr-214130
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE: This study investigated the effect of goji (Lycium chinense Mill.) on erectile dysfunction in old-aged rats. MATERIALS AND METHODS: Twenty-four 18-month-old male Sprague-Dawley rats (defined as old-aged rats) were used. Treatment groups contained eight rats each: a control group, goji extract of 150 mg/kg/day group, and goji extract of 300 mg/kg/day group. Treatment was by orogastric tube once daily for 6 weeks. After 6 weeks of treatment, testes weight, serum testosterone, superoxide dismutase, nitric oxide (NO)-cyclic guanosine monophosphate (cGMP)-related parameters, intracavernous pressure/mean arterial pressure, and histological changes were examined. RESULTS: Treatments with goji extracts increased serum testosterone level, increased the expression of endothelial NO synthase, neuronal NO synthase, and cGMP, improved the oxidative stress marker, and decreased corporal fibrosis. CONCLUSIONS: Our results indicate that goji extract may have a positive effect on erectile dysfunction via its antioxidant effects.
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Texto completo:
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Base de dados:
WPRIM
Assunto principal:
Superóxido Dismutase
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Testículo
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Testosterona
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Fibrose
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Ratos Sprague-Dawley
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Guanosina Monofosfato
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Estresse Oxidativo
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Óxido Nítrico Sintase
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Modelos Animais
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Pressão Arterial
Limite:
Animals
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Humans
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Male
Idioma:
En
Ano de publicação:
2017
Tipo de documento:
Article