Coxsackievirus B Infection Is Highly Related with Missed Abortion in Korea
Yonsei Medical Journal
; : 1562-1567, 2014.
Article
em En
| WPRIM
| ID: wpr-221606
Biblioteca responsável:
WPRO
ABSTRACT
PURPOSE:
This study investigated the possible relationship between viral infection and first trimester pregnancy loss. MATERIALS ANDMETHODS:
A prospective study was performed on 51 gravidas with missed abortion, fetal anomaly, pre-term delivery, and full-tem delivery at Hanyang University Hospital. Enteroviruses were detected by semi-nested reverse transcription-polymerase chain reaction (RT-PCR) and immunohistochemistry in abortive tissues and placentas. Enterovirus serotypes were confirmed by genome sequencing. Herpesviruses were detected by PCR.RESULTS:
Coxsackievirus B3 (CVB3) was detected in 8 of 14 missed abortion cases, 1 of 27 full-term cases, and none of the 9 pre-term cases. Coxsackievirus B1 (CVB1) was detected in an encephalocele case. Herpes simplex virus type 1 was found in 4 full-term cases, 3 pre-term cases, and none of the missed abortion cases.CONCLUSION:
The prevalence of CVB3 was significantly higher in missed abortion cases compared to full-term or pre-term delivery cases. CVB infection may therefore be an important etiological agent of missed abortion.Palavras-chave
Texto completo:
1
Base de dados:
WPRIM
Assunto principal:
Placenta
/
Complicações Infecciosas na Gravidez
/
Primeiro Trimestre da Gravidez
/
Útero
/
Imuno-Histoquímica
/
Prevalência
/
Estudos Prospectivos
/
Análise de Sequência de DNA
/
Enterovirus Humano B
/
Aborto Retido
Tipo de estudo:
Observational_studies
/
Prevalence_studies
Limite:
Adult
/
Female
/
Humans
/
Pregnancy
País como assunto:
Asia
Idioma:
En
Ano de publicação:
2014
Tipo de documento:
Article